Specificity and Kinetics of α-Synuclein Binding to Model Membranes Determined with Fluorescent Excited State Intramolecular Proton Transfer (ESIPT) Probe

Parkinson disease is characterized cytopathologically by the deposition in the midbrain of aggregates composed primarily of the presynaptic neuronal protein α-synuclein (AS). Neurotoxicity is currently attributed to oligomeric microaggregates subjected to oxidative modification and promoting mitocho...

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Bibliographic Details
Main Authors: Shvadchak, Volodymyr V., Falomir-Lockhart, Lisandro J., Yushchenko, Dmytro A., Jovin, Thomas M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075648/
https://ncbi.nlm.nih.gov/pubmed/21330368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.204776
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