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Late Activation of Stress-activated Protein Kinases/c-Jun N-terminal Kinases Triggered by Cisplatin-induced DNA Damage in Repair-defective Cells

Although stress-activated protein kinases/c-Jun N-terminal kinases (SAPK/JNK) are rapidly activated by genotoxins, the role of DNA damage in this response is not well defined. Here we show that the SEK1/MKK4-mediated dual phosphorylation of SAPK/JNK (Thr-183/Tyr-185) correlates with the level of cis...

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Autori principali: Helbig, Lars, Damrot, Julia, Hülsenbeck, Johannes, Köberle, Beate, Brozovic, Anamaria, Osmak, Maja, Fiket, Zeljka, Kaina, Bernd, Fritz, Gerhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075645/
https://ncbi.nlm.nih.gov/pubmed/21324906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.190645
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