Inflammation of the Hypothalamus Leads to Defective Pancreatic Islet Function

Type 2 diabetes mellitus results from the complex association of insulin resistance and pancreatic β-cell failure. Obesity is the main risk factor for type 2 diabetes mellitus, and recent studies have shown that, in diet-induced obesity, the hypothalamus becomes inflamed and dysfunctional, resulting...

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Detalhes bibliográficos
Main Authors: Calegari, Vivian C., Torsoni, Adriana S., Vanzela, Emerielle C., Araújo, Eliana P., Morari, Joseane, Zoppi, Claudio C., Sbragia, Lourenço, Boschero, Antonio C., Velloso, Lício A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075634/
https://ncbi.nlm.nih.gov/pubmed/21257748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.173021
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