A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin’s Regulation of Mitogenic Signaling and Tumor Suppressive Functions

The Merlin/NF2 tumor suppressor restrains cell growth and tumorigenesis by controlling contact-dependent inhibition of proliferation. We have identified a tight-junction-associated protein complex comprising Merlin, Angiomotin, Patj, and Pals1. We demonstrate that Angiomotin functions downstream of...

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Détails bibliographiques
Auteurs principaux: Yi, Chunling, Troutman, Scott, Fera, Daniela, Stemmer-Rachamimov, Anat, Avila, Jacqueline L., Christian, Neepa, Persson, Nathalie Luna, Shimono, Akihiko, Speicher, David W., Marmorstein, Ronen, Holmgren, Lars, Kissil, Joseph L.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075552/
https://ncbi.nlm.nih.gov/pubmed/21481793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.02.017
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