A Phase Two Randomised Controlled Double Blind Trial of High Dose Intravenous Methylprednisolone and Oral Prednisolone versus Intravenous Normal Saline and Oral Prednisolone in Individuals with Leprosy Type 1 Reactions and/or Nerve Function Impairment

BACKGROUND: Leprosy Type 1 reactions are a major cause of nerve damage and the preventable disability that results. Type 1 reactions are treated with oral corticosteroids and there are few data to support the optimal dose and duration of treatment. Type 1 reactions have a Th1 immune profile: cells i...

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Hauptverfasser: Walker, Stephen L., Nicholls, Peter G., Dhakal, Sushmita, Hawksworth, Rachel A., Macdonald, Murdo, Mahat, Kishori, Ruchal, Shudan, Hamal, Sushma, Hagge, Deanna A., Neupane, Kapil D., Lockwood, Diana N. J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075223/
https://ncbi.nlm.nih.gov/pubmed/21532737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001041
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