Trans-complementation by human apurinic endonuclease (Ape) of hypersensitivity to DNA damage and spontaneous mutator phenotype in apn1-yeast.

Abasic (AP) sites in DNA are potentially lethal and mutagenic. 'Class II' AP endonucleases initiate the repair of these and other DNA lesions. In yeast, the predominant enzyme of this type is Apn1, and its elimination sensitizes the cells to killing by simple alkylating agents or oxidants,...

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Main Authors: Wilson, D M, Bennett, R A, Marquis, J C, Ansari, P, Demple, B
Format: Artigo
Jezik:Inglês
Izdano: 1995
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC307509/
https://ncbi.nlm.nih.gov/pubmed/8559661
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