Phase I Trial of Two Schedules of Vincristine, Oral Irinotecan, and Temozolomide (VOIT) for Children with Relapsed or Refractory Solid Tumors: A Children's Oncology Group Phase I Consortium Study

BACKGROUND: In pre-clinical models, temozolomide and vincristine are additive or synergistic with irinotecan. We examined this 3-drug combination in children with relapsed solid tumors. Patients received orally administered irinotecan together with temozolomide and vincristine on two different sched...

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Autori principali: Wagner, Lars M., Perentesis, John P., Reid, Joel M., Ames, Matthew M., Safgren, Stephanie L., Nelson, Marvin D., Ingle, Ashish M., Blaney, Susan M., Adamson, Peter C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074342/
https://ncbi.nlm.nih.gov/pubmed/20049936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22407
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