Low Level Determinations of Methyl Methanesulfonate and Ethyl Methanesulfonate Impurities in Emtricitabine Active Pharmaceutical Ingredient by LC/MS/MS Using Electrospray Ionization

Alkyl methanesulfonates have been highlighted as potential genotoxic impurities (PGIs). A sensitive LC/MS/MS method was developed and validated for the determination of Alkyl methanesulfonate impurities in Emtricitabine API (active pharmaceutical ingredient). LC/MS/MS method on Zorbax SB C(18) colum...

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Detalhes bibliográficos
Main Authors: Kakadiya, P.R., Chandrashekhar, T.G., Ganguly, S., Singh, D.K., Singh, V.
Formato: Artigo
Idioma:Inglês
Publicado em: Libertas Academica 2011
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074210/
https://ncbi.nlm.nih.gov/pubmed/21760706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/ACI.S6471
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