Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing

MicroRNAs (miRNAs) are prevalent regulatory RNAs that mediate gene silencing and play key roles in diverse cellular processes. While synthetic RNA-based regulatory systems that integrate regulatory and sensing functions have been demonstrated, the lack of detail on miRNA structure–function relations...

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Autores principales: Beisel, Chase L., Chen, Yvonne Y., Culler, Stephanie J., Hoff, Kevin G., Smolke, Christina D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2011
Materias:
Synthetic Biology and Chemistry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074164/
https://ncbi.nlm.nih.gov/pubmed/21149259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq954
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