5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice

BACKGROUND: The role of serotonin (5-hydroxytrptamine, 5-HT) in the modulation of pain has been widely studied. Previous work led to the hypothesis that 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, might by itself influence pain thresholds. RESULTS: In the present study, we in...

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Hlavní autoři: Chen, Yong, Palm, Florian, Lesch, Klaus-Peter, Gerlach, Manfred, Moessner, Rainald, Sommer, Claudia
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073884/
https://ncbi.nlm.nih.gov/pubmed/21447193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-7-21
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