A Novel Protein Domain Induces High Affinity Selenocysteine Insertion Sequence Binding and Elongation Factor Recruitment(*)

Selenocysteine (Sec) is incorporated at UGA codons in mRNAs possessing a Sec insertion sequence (SECIS) element in their 3′-untranslated region. At least three additional factors are necessary for Sec incorporation: SECIS-binding protein 2 (SBP2), Sec-tRNA(Sec), and a Sec-specific translation elonga...

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Detalhes bibliográficos
Main Authors: Donovan, Jesse, Caban, Kelvin, Ranaweera, Ruchira, Gonzalez-Flores, Jonathan N., Copeland, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073842/
https://ncbi.nlm.nih.gov/pubmed/18948268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806008200
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