Effects of antisense-mediated inhibition of 11β-hydroxysteroid dehydrogenase type 1 on hepatic lipid metabolism

11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) converts inactive 11-keto derivatives to active glucocorticoids within tissues and may play a role in the metabolic syndrome (MS). We used an antisense oligonucleotide (ASO) to knock down 11β-HSD1 in livers of C57BL/6J mice consuming a Western-type diet...

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Autori principali: Li, Guoping, Hernandez-Ono, Antonio, Crooke, Rosanne M., Graham, Mark J., Ginsberg, Henry N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2011
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073475/
https://ncbi.nlm.nih.gov/pubmed/21364201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M013748
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