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Interferon alpha induces unabated production of short-lived plasma cells in pre-autoimmune lupus-prone (NZB×NZW)F1 mice but not in BALB/c mice

IFNα is known to play a critical role in the pathogenesis of systemic lupus erythematosus (SLE), but the mechanisms remain unclear. We previously showed that within weeks, exposure to IFNα in vivo induces lupus in pre-autoimmune lupus-prone NZB × NZW F1 (NZB/W) but not in BALB/c mice. In the current...

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Detalhes bibliográficos
Main Authors: Mathian, Alexis, Gallegos, Mike, Pascual, Virginia, Banchereau, Jacques, Koutouzov, Sophie
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073415/
https://ncbi.nlm.nih.gov/pubmed/21312191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201040649
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