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Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer

Autophagy has been reported to be increased in irradiated cancer cells resistant to various apoptotic stimuli. We therefore hypothesized that induction of autophagy via mTOR inhibition could enhance radiosensitization in apoptosis-inhibited H460 lung cancer cells in vitro and in a lung cancer xenogr...

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Main Authors: Kim, Kwang Woon, Hwang, Misun, Moretti, Luigi, Jaboin, Jerry J., Cha, Yong I., Lu, Bo
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073356/
https://ncbi.nlm.nih.gov/pubmed/18424912
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