Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window

To understand the cellular and circuit mechanisms of experience-dependent plasticity, neurons and their synapses need to be studied in the intact brain over extended periods of time. Two-photon excitation laser scanning microscopy (2PLSM), together with expression of fluorescent proteins, enables hi...

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Autori principali: Holtmaat, Anthony, Bonhoeffer, Tobias, Chow, David K, Chuckowree, Jyoti, De Paola, Vincenzo, Hofer, Sonja B, Hübener, Mark, Keck, Tara, Knott, Graham, Lee, Wei-Chung A, Mostany, Ricardo, Mrsic-Flogel, Tom D, Nedivi, Elly, Portera-Cailliau, Carlos, Svoboda, Karel, Trachtenberg, Joshua T, Wilbrecht, Linda
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072839/
https://ncbi.nlm.nih.gov/pubmed/19617885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2009.89
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