Nine Orders of Magnitude Dynamic Range: Picomolar to Millimolar Concentration Measurement in Capillary Electrophoresis with Laser Induced Fluorescence Detection Employing Cascaded Avalanche Photodiode Photon Counters

The dynamic range of capillary electrophoresis analysis is ultimately limited by molecular shot noise at low concentrations and by concentration-induced band broadening at high concentrations. We report a system that approaches these fundamental limits. A laser-induced fluorescence detector is repor...

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Bibliographic Details
Main Authors: Dada, Oluwatosin O., Essaka, David C., Hindsgaul, Ole, Palcic, Monica M., Prendergast, Jillian, Schnaar, Ronald L., Dovichi, Norman J.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072807/
https://ncbi.nlm.nih.gov/pubmed/21410138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac103374x
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