A phase I trial to evaluate the safety and pharmacokinetics of low-dose methotrexate as an anti-malarial drug in Kenyan adult healthy volunteers

BACKGROUND: Previous investigations indicate that methotrexate, an old anticancer drug, could be used at low doses to treat malaria. A phase I evaluation was conducted to assess the safety and pharmacokinetic profile of this drug in healthy adult male Kenyan volunteers. METHODS: Twenty five healthy...

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Hlavní autoři: Chilengi, Roma, Juma, Rashid, Abdallah, Ahmed M, Bashraheil, Mahfudh, Lodenyo, Hudson, Nyakundi, Priscilla, Anabwani, Evelyn, Salim, Amina, Mwambingu, Gabriel, Wenwa, Ednah, Jemutai, Julie, Kipkeu, Chemtai, Oyoo, George O, Muchohi, Simon N, Kokwaro, Gilbert, Niehues, Tim, Lang, Trudie, Nzila, Alexis
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072355/
https://ncbi.nlm.nih.gov/pubmed/21410944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-10-63
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