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One Process for Pancreatic β-Cell Coalescence into Islets Involves an Epithelial-Mesenchymal Transition

Islet replacement is a promising therapy for treating Diabetes Mellitus, but the supply of donor tissue for transplantation is limited. To overcome this limitation, endocrine tissue can be expanded, but this requires an understanding of normal developmental processes that regulate islet formation. I...

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Autors principals: Cole, Lori, Anderson, Miranda, Antin, Parker B., Limesand, Sean W.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071757/
https://ncbi.nlm.nih.gov/pubmed/19608613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JOE-09-0072
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