Carriage of the V279F Null Allele within the Gene Encoding Lp-PLA(2) Is Protective from Coronary Artery Disease in South Korean Males

BACKGROUND: The Asia-specific PLA2G7 994G-T transversion leads to V279F substitution within the lipoprotein-associated phospholipase-A2 (Lp-PLA(2)) and to absence of enzyme activity in plasma. This variant offers a unique natural experiment to assess the role of Lp-PLA(2) in the pathogenesis of coro...

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Main Authors: Jang, Yangsoo, Waterworth, Dawn, Lee, Jong-Eun, Song, Kijoung, Kim, Sujin, Kim, Hyo-Soo, Park, Kyung Woo, Cho, Hyun-Jai, Oh, Il-Young, Park, Jeong Euy, Lee, Bok-Soo, Ku, Hyo Jeong, Shin, Dong-Jik, Lee, Jong Ho, Jee, Sun Ha, Han, Bok-Ghee, Jang, Hye-Yoon, Cho, Eun-Young, Vallance, Patrick, Whittaker, John, Cardon, Lon, Mooser, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071750/
https://ncbi.nlm.nih.gov/pubmed/21490708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018208
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