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HIV Infection Enhances TRAIL-Induced Cell Death in Macrophage by Down-Regulating Decoy Receptor Expression and Generation of Reactive Oxygen Species

BACKGROUND: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) could induce apoptosis of HIV-1-infected monocyte-derived macrophage (MDM), but the molecular mechanisms are not well understood. METHODOLOGY/PRINCIPAL FINDINGS: By using an HIV-1 Env-pseudotyped virus (HIV-1 PV)-infected MD...

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Detalhes bibliográficos
Main Authors: Zhu, Dan-Ming, Shi, Juan, Liu, Shilian, Liu, Yanxin, Zheng, Dexian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071698/
https://ncbi.nlm.nih.gov/pubmed/21483669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018291
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