Exercise Training Stimulates Ischemia-Induced Neovascularization via Phosphatidylinositol 3-Kinase/Akt-Dependent Hypoxia-Induced Factor-1α Reactivation in Mice of Advanced Age

BACKGROUND: Exercise stimulates the vascular response in pathological conditions, including ischemia; however, the molecular mechanisms by which exercise improves the impaired hypoxia-induced factor (HIF)-1α–mediated response to hypoxia associated with aging are poorly understood. Here, we report th...

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Detalhes bibliográficos
Main Authors: Cheng, Xian Wu, Kuzuya, Masafumi, Kim, Weon, Song, Haizhen, Hu, Lina, Inoue, Aiko, Nakamura, Kae, Di, Qun, Sasaki, Takeshi, Tsuzuki, Michitaka, Shi, Guo-Ping, Okumura, Kenji, Murohara, Toyoaki
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071504/
https://ncbi.nlm.nih.gov/pubmed/20679550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.909218
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