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Molecular chaperones and substrate ubiquitination control the efficiency of endoplasmic reticulum-associated degradation

The endoplasmic reticulum (ER) must contend with a large protein flux, which is especially notable in cells dedicated to secreting hormone-regulated gene products. Because of the complexity of the protein folding pathway and the potential for genetic or stochastic errors, a significant percentage of...

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Detalhes bibliográficos
Main Authors: Goeckeler, J. L., Brodsky, J. L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071497/
https://ncbi.nlm.nih.gov/pubmed/21029298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1463-1326.2010.01273.x
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