Simvastatin Stimulates Apoptosis in Cholangiocarcinoma by Inhibition of Rac1 Activity

BACKGROUND: Simvastatin is a cholesterol-lowering drug that is widely used to prevent and treat atherosclerotic cardiovascular disease. Simvastatin exhibits numerous pleiotropic effects including anti-cancer activity. However, the effect of simvastatin on cholangiocarcinoma has not been evaluated. A...

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Bibliografische gegevens
Hoofdauteurs: Miller, Timothy, Yang, Fuquan, Wise, Candace E., Meng, Fanyin, Priester, Sally, Munshi, Md Kamruzzaman, Guerrier, Dostal, David E., Glaser, Shannon S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071437/
https://ncbi.nlm.nih.gov/pubmed/21334995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dld.2011.01.010
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