Novel Trisubstituted Benzimidazoles, Targeting Mtb FtsZ, As A New Class of Antitubercular Agents

Libraries of novel trisubstituted benzimidazoles were created through rational drug design. A good number of these benzimidazoles exhibited promising MIC values in the range of 0.5-6 μg/mL (2-15 μM) for their antibacterial activity against Mtb H37Rv strain. Moreover, five of the lead compounds also...

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Bibliografiske detaljer
Main Authors: Kumar, Kunal, Awasthi, Divya, Lee, Seung-Yub, Zanardi, Ilaria, Ruzsicska, Bela, Knudson, Susan, Tonge, Peter J., Slayden, Richard A., Ojima, Iwao
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071426/
https://ncbi.nlm.nih.gov/pubmed/21126020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1012006
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