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Radically different amyloid conformations dictate the seeding specificity of a chimeric Sup35 prion

A remarkable feature of prion biology is that the same prion protein can misfold into more than one infectious conformation and these conformations, in turn, lead to distinct heritable prion strains with different phenotypes. The yeast prion [PSI(+)] is a powerful system for studying how changes in...

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Autors principals: Foo, Catherine K., Ohhashi, Yumiko, Kelly, Mark J. S., Tanaka, Motomasa, Weissman, Jonathan S.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070826/
https://ncbi.nlm.nih.gov/pubmed/21333653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.02.025
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