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Polyamine effects on purine-purine-pyrimidine triple helix formation by phosphodiester and phosphorothioate oligodeoxyribonucleotides.

Utilization of oligodeoxyribonucleotides to inhibit specific gene transcription in vivo (antigene strategy) requires the efficient formation of triple helices under physiological conditions. However, pyrimidine-motif triplexes are not favored at physiological pH, and physiological concentrations of...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Musso, M, Van Dyke, M W
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 1995
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307024/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7610062/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.12.2320
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