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Normal Modes of Prion Proteins: From Native to Infectious particle

Prion proteins (PrP) are the infectious agent in transmissible spongiform encephalopathies (i.e. mad cow disease). To be infectious, prion proteins must undergo a conformational change involving a decrease of α-helical content along with an increase of β-strand structure. This conformational change...

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Autors principals: Samson, Abraham O., Levitt, Michael
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070235/
https://ncbi.nlm.nih.gov/pubmed/21338080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1010514
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