Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model

BACKGROUND & AIMS: In this study, we sought to determine the temporal relationship between hepatic mitochondrial dysfunction, hepatic steatosis and insulin resistance, and to examine their potential role in the natural progression of non-alcoholic fatty liver disease (NAFLD) utilising a sedentar...

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Bibliografiske detaljer
Main Authors: Rector, R. Scott, Thyfault, John P., Uptergrove, Grace M., Morris, E. Matthew, Naples, Scott P., Borengasser, Sarah J., Mikus, Catherine R., Laye, Matthew J., Laughlin, M. Harold, Booth, Frank W., Ibdah, Jamal A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070177/
https://ncbi.nlm.nih.gov/pubmed/20347174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2009.11.030
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