Retroviral Vectors Induce Epigenetic Chromatin Modifications and IL-10 Production in Transduced B Cells via Activation of Toll-like Receptor 2

The immune response toward viral vectors used for gene therapy and genetic vaccination appears to be critically important in determining the therapeutic outcome. However, the mechanisms that control the immune response following gene transfer are poorly understood. Unexpectedly, we found that integr...

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Bibliographische Detailangaben
Hauptverfasser: Ahangarani, Roxana R, Janssens, Wim, Carlier, Vincent, VanderElst, Luc, VandenDriessche, Thierry, Chuah, Marinee, Jacquemin, Marc, Saint-Remy, Jean-Marie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070090/
https://ncbi.nlm.nih.gov/pubmed/21157434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.275
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