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Substrate specificity and catalysis by the editing active site of alanyl-tRNA synthetase from Escherichia coli
Aminoacyl-tRNA synthetases (ARSs) enhance the fidelity of protein synthesis through multiple mechanisms, including hydrolysis of the adenylate and cleavage of misacylated tRNA. Alanyl-tRNA synthetase (AlaRS) limits misacylation with glycine and serine by use of a dedicated editing domain, and a muta...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3069921/ https://ncbi.nlm.nih.gov/pubmed/21241052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1013535 |
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