Site-specific cleavage of chromosomes in vitro through Cre-lox recombination.

Site-specific recombination systems are useful tools for chromosome engineering in vivo and site-specific DNA cleavage methods have applications in genome analysis and gene isolation. Here, we report a new method to fragment chromosomes in vitro using the Cre-lox site-specific recombination system....

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Bibliographic Details
Main Authors: Qin, M, Lee, E, Zankel, T, Ow, D W
Format: Artigo
Language:Inglês
Published: 1995
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC306964/
https://ncbi.nlm.nih.gov/pubmed/7596819
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