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Selective Mutations in Estrogen Receptor α D-domain Alters Nuclear Translocation and Non-estrogen Response Element Gene Regulatory Mechanisms

The three main mechanisms of ERα action are: 1) nuclear, genomic, direct DNA binding, 2) nuclear, genomic, “tethered”-mediated, protein-protein interactions, and 3) non-nuclear, non-genomic, rapid action responses. Reports suggest the D-domain or hinge region of ERα plays an important role in mechan...

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Bibliografiske detaljer
Main Authors: Burns, Katherine A., Li, Yin, Arao, Yukitomo, Petrovich, Robert M., Korach, Kenneth S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069464/
https://ncbi.nlm.nih.gov/pubmed/21285458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.187773
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