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Structural and Biochemical Studies of Serine Acetyltransferase Reveal Why the Parasite Entamoeba histolytica Cannot Form a Cysteine Synthase Complex

Cysteine (Cys) plays a major role in growth and survival of the human parasite Entamoeba histolytica. We report here the crystal structure of serine acetyltransferase (SAT) isoform 1, a cysteine biosynthetic pathway enzyme from E. histolytica (EhSAT1) at 1.77 Å, in complex with its substrate serine...

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Autors principals: Kumar, Sudhir, Raj, Isha, Nagpal, Isha, Subbarao, Naidu, Gourinath, Samudrala
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069455/
https://ncbi.nlm.nih.gov/pubmed/21297164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.197376
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