A phase 1 dose-escalation study: safety, tolerability, and pharmacokinetics of FBS0701, a novel oral iron chelator for the treatment of transfusional iron overload

BACKGROUND: There is still a clinical need for a well-tolerated and safe iron chelator for the treatment of transfusional iron overload. We describe the pharmacokinetic properties and safety data after 7 days of dosing of FBS0701, a novel oral, once-daily iron chelator. DESIGN AND METHODS: This phas...

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Detalhes bibliográficos
Main Authors: Rienhoff, Hugh Young, Viprakasit, Vip, Tay, Lay, Harmatz, Paul, Vichinsky, Elliott, Chirnomas, Deborah, Kwiatkowski, Janet L., Tapper, Amy, Kramer, William, Porter, John B., Neufeld, Ellis J.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069228/
https://ncbi.nlm.nih.gov/pubmed/21173101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.034405
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