Ancestral Mutation in Telomerase Causes Defects in Repeat Addition Processivity and Manifests As Familial Pulmonary Fibrosis

The telomerase reverse transcriptase synthesizes new telomeres onto chromosome ends by copying from a short template within its integral RNA component. During telomere synthesis, telomerase adds multiple short DNA repeats successively, a property known as repeat addition processivity. However, the c...

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Hauptverfasser: Alder, Jonathan K., Cogan, Joy D., Brown, Andrew F., Anderson, Collin J., Lawson, William E., Lansdorp, Peter M., Phillips, John A., Loyd, James E., Chen, Julian J.-L., Armanios, Mary
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069110/
https://ncbi.nlm.nih.gov/pubmed/21483807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001352
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