Activated Protein Synthesis and Suppressed Protein Breakdown Signaling in Skeletal Muscle of Critically Ill Patients

BACKGROUND: Skeletal muscle mass is controlled by myostatin and Akt-dependent signaling on mammalian target of rapamycin (mTOR), glycogen synthase kinase 3β (GSK3β) and forkhead box O (FoxO) pathways, but it is unknown how these pathways are regulated in critically ill human muscle. To describe fact...

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Hauptverfasser: Jespersen, Jakob G., Nedergaard, Anders, Reitelseder, Søren, Mikkelsen, Ulla R., Dideriksen, Kasper J., Agergaard, Jakob, Kreiner, Frederik, Pott, Frank C., Schjerling, Peter, Kjaer, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069050/
https://ncbi.nlm.nih.gov/pubmed/21483870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018090
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