Infliximab Induces Clonal Expansion of γδ-T Cells in Crohn's Disease: A Predictor of Lymphoma Risk?

BACKGROUND: Concominant with the widespread use of combined immunotherapy in the management of Crohn's disease (CD), the incidence of hepato-splenic gamma-delta (γδ)-T cell lymphoma has increased sharply in CD patients. Malignant transformation of lymphocytes is believed to be a multistep proce...

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Main Authors: Kelsen, Jens, Dige, Anders, Schwindt, Heinrich, D'Amore, Francesco, Pedersen, Finn S., Agnholt, Jørgen, Christensen, Lisbet A., Dahlerup, Jens F., Hvas, Christian L.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069033/
https://ncbi.nlm.nih.gov/pubmed/21483853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017890
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