Exploring Off-Targets and Off-Systems for Adverse Drug Reactions via Chemical-Protein Interactome — Clozapine-Induced Agranulocytosis as a Case Study

In the era of personalized medical practice, understanding the genetic basis of patient-specific adverse drug reaction (ADR) is a major challenge. Clozapine provides effective treatments for schizophrenia but its usage is limited because of life-threatening agranulocytosis. A recent high impact stud...

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Detalhes bibliográficos
Main Authors: Yang, Lun, Wang, Kejian, Chen, Jian, Jegga, Anil G., Luo, Heng, Shi, Leming, Wan, Chunling, Guo, Xizhi, Qin, Shengying, He, Guang, Feng, Guoyin, He, Lin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068927/
https://ncbi.nlm.nih.gov/pubmed/21483481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002016
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