Rational Approach to Select Small Peptide Molecular Probes Labeled with Fluorescent Cyanine Dyes for in vivo Optical Imaging

We demonstrate that the structure of carbocyanine dyes, which are commonly used to label small peptides for molecular imaging, and not the bound peptide, controls the rate of extravasation from blood vessels to tissue. By examining several near-infrared (NIR) carbocyanine fluorophores, we demonstrat...

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Main Authors: Berezin, Mikhail Y., Guo, Kevin, Akers, Walter, Livingston, Joseph, Solomon, Metasebya, Lee, Hyeran, Liang, Kexian, Agee, Anthony, Achilefu, Samuel
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068226/
https://ncbi.nlm.nih.gov/pubmed/21329363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2000966
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