Kaposi's Sarcoma-Associated Herpesvirus-Induced Angiogenin Plays Roles in Latency via the Phospholipase Cγ Pathway: Blocking Angiogenin Inhibits Latent Gene Expression and Induces the Lytic Cycle

During de novo infection of human dermal microvascular endothelial cells (HMVEC-d), Kaposi's sarcoma-associated herpesvirus (KSHV) induced the multifunctional angiogenin (ANG) protein, which entered the nuclei and nucleoli of infected cells and stimulated 45S rRNA gene transcription, proliferat...

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Detalhes bibliográficos
Main Authors: Sadagopan, Sathish, Valiya Veettil, Mohanan, Paudel, Nitika, Bottero, Virginie, Chandran, Bala
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067939/
https://ncbi.nlm.nih.gov/pubmed/21209106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01532-10
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