Membrane Environment Exerts an Important Influence on Rac-Mediated Activation of Phospholipase Cγ2

We performed analyses of the molecular mechanisms involved in the regulation of phospholipase Cγ2 (PLCγ2). We identified several regions in the PLCγ-specific array, γSA, that contribute to autoinhibition in the basal state by occlusion of the catalytic domain. While the activation of PLCγ2 by Rac2 r...

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Main Authors: Everett, Katy L., Buehler, Anja, Bunney, Tom D., Margineanu, Anca, Baxendale, Rhona W., Vatter, Petra, Retlich, Michael, Walliser, Claudia, Manning, Hugh B., Neil, Mark A. A., Dunsby, Christopher, French, Paul M. W., Gierschik, Peter, Katan, Matilda
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067904/
https://ncbi.nlm.nih.gov/pubmed/21245382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01408-10
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