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Glutamic acid decarboxylase and glutamate receptor changes during tolerance and dependence to benzodiazepines
Protracted administration of diazepam elicits tolerance, whereas discontinuation of treatment results in signs of dependence. Tolerance to the anticonvulsant action of diazepam is present in an early phase (6, 24, and 36 h) but disappears in a late phase (72–96 h) of withdrawal. In contrast, signs o...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The National Academy of Sciences
2001
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC30679/ https://ncbi.nlm.nih.gov/pubmed/11248104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051628698 |
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