Human Cytomegalovirus Disrupts the Major Histocompatibility Complex Class I Peptide-Loading Complex and Inhibits Tapasin Gene Transcription

Major histocompatibility complex class I (MHC I) molecules present antigenic peptides for CD8(+) T-cell recognition. Prior to cell surface expression, proper MHC I loading is conducted by the peptide-loading complex (PLC), composed of the MHC I heavy chain (HC) and β(2)-microglobulin (β(2)m), the pe...

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Main Authors: Halenius, Anne, Hauka, Sebastian, Dölken, Lars, Stindt, Jan, Reinhard, Henrike, Wiek, Constanze, Hanenberg, Helmut, Koszinowski, Ulrich H., Momburg, Frank, Hengel, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2011
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067861/
https://ncbi.nlm.nih.gov/pubmed/21248040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01923-10
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