The V1V2 Domain and an N-Linked Glycosylation Site in the V3 Loop of the HIV-1 Envelope Glycoprotein Modulate Neutralization Sensitivity to the Human Broadly Neutralizing Antibody 2G12

The broadly neutralizing human monoclonal antibody 2G12 binds to a carbohydrate-dependent epitope involving three major potential N-linked glycosylation sites (PNGS) of gp120 (N295, N332, and N392). Through analysis of the sensitivity to 2G12 of pseudotyped viruses carrying envelope proteins from HI...

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Detalhes bibliográficos
Main Authors: Chaillon, Antoine, Braibant, Martine, Moreau, Thierry, Thenin, Suzie, Moreau, Alain, Autran, Brigitte, Barin, Francis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067857/
https://ncbi.nlm.nih.gov/pubmed/21248038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02424-10
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