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The Sporulation Protein SirA Inhibits the Binding of DnaA to the Origin of Replication by Contacting a Patch of Clustered Amino Acids

Bacteria regulate the frequency and timing of DNA replication initiation by controlling the activity of the replication initiator protein DnaA. SirA is a recently discovered regulator of DnaA in Bacillus subtilis whose synthesis is turned on at the start of sporulation. Here, we demonstrate that Sir...

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Bibliografske podrobnosti
Main Authors: Rahn-Lee, Lilah, Merrikh, Houra, Grossman, Alan D., Losick, Richard
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067619/
https://ncbi.nlm.nih.gov/pubmed/21239581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01390-10
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