The Cluster 1 Type VI Secretion System Is a Major Virulence Determinant in Burkholderia pseudomallei

The Burkholderia pseudomallei K96243 genome encodes six type VI secretion systems (T6SSs), but little is known about the role of these systems in the biology of B. pseudomallei. In this study, we purified recombinant Hcp proteins from each T6SS and tested them as vaccine candidates in the BALB/c mou...

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Autori principali: Burtnick, Mary N., Brett, Paul J., Harding, Sarah V., Ngugi, Sarah A., Ribot, Wilson J., Chantratita, Narisara, Scorpio, Angelo, Milne, Timothy S., Dean, Rachel E., Fritz, David L., Peacock, Sharon J., Prior, Joanne L., Atkins, Timothy P., DeShazer, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2011
Soggetti:
Molecular Pathogenesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067527/
https://ncbi.nlm.nih.gov/pubmed/21300775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01218-10
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