Hsp110-Mediated Enhancement of CD4(+) T Cell Responses to the Envelope Glycoprotein of Members of the Family Flaviviridae In Vitro Does Not Occur In Vivo

The use of heat shock proteins (HSP) to enhance activation of the immune response to chaperoned antigen is being explored for immunotherapy. Hsp110 chaperones large protein substrates more effectively than Hsp70, offering the potential to use complex antigens containing multiple epitopes in HSP-base...

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Detalhes bibliográficos
Main Authors: McLaughlin, Kerry, Carr, Veronica B., Iqbal, Munir, Seago, Julian, Lefevre, Eric A., Robinson, Lucy, Prentice, Helen, Charleston, Bryan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Microbial Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067363/
https://ncbi.nlm.nih.gov/pubmed/21147937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00414-10
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