Use of Pharmacokinetic and Pharmacodynamic Principles To Determine Optimal Administration of Daptomycin in Patients Receiving Standardized Thrice-Weekly Hemodialysis

This study identified optimal daptomycin dosing for patients receiving thrice-weekly hemodialysis (HD). Twelve adult patients on HD received daptomycin at 6 mg/kg of body weight intravenously (i.v.) one time; plasma and dialysate samples were collected over 3 days. A 2-compartment model with separat...

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Main Authors: Patel, Nimish, Cardone, Katie, Grabe, Darren W., Meola, Shari, Hoy, Christopher, Manley, Harold, Drusano, George L., Lodise, Thomas P.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2011
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067175/
https://ncbi.nlm.nih.gov/pubmed/21282429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01224-10
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