Effect of Half-Life on the Pharmacodynamic Index of Zanamivir against Influenza Virus Delineated by a Mathematical Model

Intravenous zanamivir is recommended for the treatment of hospitalized patients with complicated oseltamivir-resistant influenza virus infections. In a companion paper, we show that the time above the 50% effective concentration (time>EC(50)) is the pharmacodynamic (PD) index predicting the inhib...

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Hlavní autoři: Brown, Ashley N., Bulitta, Jürgen B., McSharry, James J., Weng, Qingmei, Adams, Jonathan R., Kulawy, Robert, Drusano, George L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2011
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067163/
https://ncbi.nlm.nih.gov/pubmed/21263045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01629-10
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