Antimicrobial Resistance among Invasive Nontyphoidal Salmonella enterica Isolates in the United States: National Antimicrobial Resistance Monitoring System, 1996 to 2007

Nontyphoidal salmonellae (NTS) are important causes of community-acquired bloodstream infection. We describe patterns of antimicrobial resistance among invasive NTS in the United States. We compared bloodstream NTS isolates with those from stool submitted to the National Antimicrobial Resistance Mon...

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Main Authors: Crump, John A., Medalla, Felicita M., Joyce, Kevin W., Krueger, Amy L., Hoekstra, R. Michael, Whichard, Jean M., Barzilay, Ezra J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067073/
https://ncbi.nlm.nih.gov/pubmed/21199924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01333-10
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spelling pubmed-30670732011-09-01 Antimicrobial Resistance among Invasive Nontyphoidal Salmonella enterica Isolates in the United States: National Antimicrobial Resistance Monitoring System, 1996 to 2007 Crump, John A. Medalla, Felicita M. Joyce, Kevin W. Krueger, Amy L. Hoekstra, R. Michael Whichard, Jean M. Barzilay, Ezra J. Antimicrob Agents Chemother Epidemiology and Surveillance Nontyphoidal salmonellae (NTS) are important causes of community-acquired bloodstream infection. We describe patterns of antimicrobial resistance among invasive NTS in the United States. We compared bloodstream NTS isolates with those from stool submitted to the National Antimicrobial Resistance Monitoring System (NARMS) from 1996 to 2007. We describe antimicrobial resistance among invasive strains by serogroup and serotype. Of the 19,302 NTS isolates, 17,804 (92.2%) were from stool or blood. Of these, 1,050 (5.9%) were bloodstream isolates. The median ages (ranges) of patients with and without bacteremia were 36 (<1 to 97) years and 20 (<1 to 105) years, respectively (P < 0.001). Males (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.06 to 1.38) and those ≥65 years of age were at greater risk for invasive disease. Salmonella enterica serotypes Enteritidis, Typhimurium, and Heidelberg were the most common serotypes isolated from blood; S. enterica serotypes Dublin, Sandiego, and Schwarzengrund were associated with the greatest risk for bloodstream isolation. Of invasive isolates, 208 (19.8%) were resistant to ampicillin, 117 (11.1%) to chloramphenicol, and 26 (2.5%) to trimethoprim-sulfamethoxazole; 28 (2.7%) isolates were resistant to nalidixic acid and 26 (2.5%) to ceftriaxone. Antimicrobial resistance to traditional agents is common. However, the occurrence of nalidixic acid and ceftriaxone resistance among invasive NTS is cause for clinical and public health vigilance. American Society for Microbiology (ASM) 2011-03 2011-01-03 /pmc/articles/PMC3067073/ /pubmed/21199924 http://dx.doi.org/10.1128/AAC.01333-10 Text en Copyright © 2011, American Society for Microbiology
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Epidemiology and Surveillance
spellingShingle Epidemiology and Surveillance
Crump, John A.
Medalla, Felicita M.
Joyce, Kevin W.
Krueger, Amy L.
Hoekstra, R. Michael
Whichard, Jean M.
Barzilay, Ezra J.
Antimicrobial Resistance among Invasive Nontyphoidal Salmonella enterica Isolates in the United States: National Antimicrobial Resistance Monitoring System, 1996 to 2007
description Nontyphoidal salmonellae (NTS) are important causes of community-acquired bloodstream infection. We describe patterns of antimicrobial resistance among invasive NTS in the United States. We compared bloodstream NTS isolates with those from stool submitted to the National Antimicrobial Resistance Monitoring System (NARMS) from 1996 to 2007. We describe antimicrobial resistance among invasive strains by serogroup and serotype. Of the 19,302 NTS isolates, 17,804 (92.2%) were from stool or blood. Of these, 1,050 (5.9%) were bloodstream isolates. The median ages (ranges) of patients with and without bacteremia were 36 (<1 to 97) years and 20 (<1 to 105) years, respectively (P < 0.001). Males (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.06 to 1.38) and those ≥65 years of age were at greater risk for invasive disease. Salmonella enterica serotypes Enteritidis, Typhimurium, and Heidelberg were the most common serotypes isolated from blood; S. enterica serotypes Dublin, Sandiego, and Schwarzengrund were associated with the greatest risk for bloodstream isolation. Of invasive isolates, 208 (19.8%) were resistant to ampicillin, 117 (11.1%) to chloramphenicol, and 26 (2.5%) to trimethoprim-sulfamethoxazole; 28 (2.7%) isolates were resistant to nalidixic acid and 26 (2.5%) to ceftriaxone. Antimicrobial resistance to traditional agents is common. However, the occurrence of nalidixic acid and ceftriaxone resistance among invasive NTS is cause for clinical and public health vigilance.
author Crump, John A.
Medalla, Felicita M.
Joyce, Kevin W.
Krueger, Amy L.
Hoekstra, R. Michael
Whichard, Jean M.
Barzilay, Ezra J.
author_facet Crump, John A.
Medalla, Felicita M.
Joyce, Kevin W.
Krueger, Amy L.
Hoekstra, R. Michael
Whichard, Jean M.
Barzilay, Ezra J.
author_sort Crump, John A.
title Antimicrobial Resistance among Invasive Nontyphoidal Salmonella enterica Isolates in the United States: National Antimicrobial Resistance Monitoring System, 1996 to 2007
title_short Antimicrobial Resistance among Invasive Nontyphoidal Salmonella enterica Isolates in the United States: National Antimicrobial Resistance Monitoring System, 1996 to 2007
title_full Antimicrobial Resistance among Invasive Nontyphoidal Salmonella enterica Isolates in the United States: National Antimicrobial Resistance Monitoring System, 1996 to 2007
title_fullStr Antimicrobial Resistance among Invasive Nontyphoidal Salmonella enterica Isolates in the United States: National Antimicrobial Resistance Monitoring System, 1996 to 2007
title_full_unstemmed Antimicrobial Resistance among Invasive Nontyphoidal Salmonella enterica Isolates in the United States: National Antimicrobial Resistance Monitoring System, 1996 to 2007
title_sort antimicrobial resistance among invasive nontyphoidal salmonella enterica isolates in the united states: national antimicrobial resistance monitoring system, 1996 to 2007
publisher American Society for Microbiology (ASM)
publishDate 2011
url https://ncbi.nlm.nih.gov/pmc/articles/PMC3067073/
https://ncbi.nlm.nih.gov/pubmed/21199924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01333-10
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